An iridoid glycoside with diverse biological activities; reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation at 0.1 mg/pouch; prevents prevents carrageenan-induced paw edema in rats at 100 mg/kg

Geniposide – 100 mg

Brand:
Cayman
CAS:
24512-63-8
Storage:
-20
UN-No:
Non-Hazardous - /

Geniposide is an iridoid glycoside that has been found in G. jasmonoides fruit and has diverse biological activities.{50311,50312,50313} It reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation when administered at a dose of 0.1 mg/pouch.{50311} Geniposide (100 mg/kg, p.o.) prevents carrageenan-induced paw edema in rats. It reduces serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) and hepatic levels of malondialdehyde (MDA), as well as increases hepatic levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in a rat model of high-fat diet-induced nonalcoholic steatohepatitis (NASH) when administered at doses of 50 and 100 mg/kg.{50312} Geniposide (100 mg/kg) prevents increases in apoptosis and decreases in the number of dopaminergic neurons in the substantia nigra in a mouse model of MPTP-induced Parkinson’s disease.{50313} It also improves motor coordination in the rotarod and swim tests in a rat model of Parkinson’s disease.  

 

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SKU: 28281 - 100 mg Category:

Description

An iridoid glycoside with diverse biological activities; reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation at 0.1 mg/pouch; prevents prevents carrageenan-induced paw edema in rats at 100 mg/kg, p.o.; reduces serum levels of ALT and AST and hepatic levels of MDA as well as decreases in hepatic levels of SOD and GPX in a rat model of high-fat diet-induced NASH at 50 and 100 mg/kg; prevents increases in apoptosis and decreases in the number of dopaminergic neurons in the substantia nigra in a mouse model of MPTP-induced Parkinson’s disease at 100 mg/kg; improves motor coordination in the rotarod and swim tests in a rat model of Parkinson’s disease

Formal name: (1S,4aS,7aS)-1-(β-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 388.4

CAS: 24512-63-8

Purity: ≥98%

Formulation: A crystalline solid

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