A broad-spectrum fluoroquinolone antibiotic; inhibits growth of N. gonorrhoeae

Lomefloxacin (hydrochloride) – 5 g

Brand:
Cayman
CAS:
98079-52-8
Storage:
-20
UN-No:
Non-Hazardous - /

Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic.{47586} In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth.{47587} Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.  

 

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SKU: 28271 - 5 g Category:

Description

A broad-spectrum fluoroquinolone antibiotic; inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively); inhibits growth of S. aureus and MRSA (MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both); inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection

Formal name: 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride

Synonyms:  SC-47111

Molecular weight: 387.8

CAS: 98079-52-8

Purity: ≥98%

Formulation: A crystalline solid

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