A macrocyclic dilactone with diverse biological activities; cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml); inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml); potentiates the activity of polymyxin B against B. cenocepacia; active against T. spiralis in vitro and in vivo

IKD-8344 – 1 mg

Brand:
Cayman
CAS:
129046-69-1
Storage:
-20
UN-No:
Non-Hazardous - /

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.{52214,52215,52216} It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).{52214} IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B (Item No. 14157) against the multidrug-resistant pathogenic bacterium B. cenocepacia.{52215,52216} It is active against T. spiralis in vitro and in vivo.{52214}  

 

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SKU: 28194 - 1 mg Category:

Description

A macrocyclic dilactone with diverse biological activities; cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml); inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml); potentiates the activity of polymyxin B against B. cenocepacia; active against T. spiralis in vitro and in vivo

Formal name: (1R,2R,5S,8S,9S,12R,14S,17R,18R,21S,24S,25S,28R,30S)-rel-2,9,18,25-tetramethyl-12,28-bis[(1S)-1-[(2S,5R)-tetrahydro-5-methyl-2-furanyl]ethyl]-11,27,33,34,35,36-hexaoxapentacyclo[28.2.1.15,8.114,17.121,24]hexatriacontane-3,10,19,26-tetrone

Synonyms: 

Molecular weight: 845.1

CAS: 129046-69-1

Purity: ≥70%

Formulation: A solid

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