A peptide with antibacterial and antiviral activities; active against Gram-positive bacteria (MICs = 32-64 µg/ml); inhibits HIV viral replication in H9 cells (IC50 = ~5 µM); active against clinical isolates of HIV-1 from clades A-D

Feglymycin – 1 mg

Brand:
Cayman
CAS:
209335-49-9
Storage:
-20
UN-No:
Non-Hazardous - /

Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities.{43957} It is active against Gram-positive bacteria (MICs = 32-64 µg/ml) and inhibits HIV viral replication in H9 cells (IC50 = ~5 µM). Feglymycin is also active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 µM).{43958} It interacts with gp120 and inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 µM) and to CD4+ SupT1 T cells by 74.5% when used at a concentration of 10.5 µM. Feglymycin inhibits the E. coli peptidoglycan biosynthesis enzymes MurA and MurC (Kis = 3.4 and 0.3 µM, respectively) in a noncompetitive manner.{43959}  

 

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SKU: 28166 - 1 mg Category:

Description

A peptide with antibacterial and antiviral activities; active against Gram-positive bacteria (MICs = 32-64 µg/ml); inhibits HIV viral replication in H9 cells (IC50 = ~5 µM); active against clinical isolates of HIV-1 from clades A-D, A/E, and G (EC50s = 0.5-6.7 µM); inhibits HIV-1 NL4.3 binding to human soluble CD4 (EC50 = 4.4 µM) and to CD4+ SupT1 T cells by 74.5% at 10.5 µM; inhibits the E. coli peptidoglycan biosynthesis enzymes MurA and MurC (Kis = 3.4 and 0.3 µM, respectively)

Formal name: (2R)-2-(4-hydroxyphenyl)glycyl-(2R)-2-(3,5-dihydroxyphenyl)glycyl-L-valyl-(2R)-2-(3,5-dihydroxyphenyl)glycyl-(2S)-2-(4-hydroxyphenyl)glycyl-(2R)-2-(3,5-dihydroxyphenyl)glycyl-(2S)-2-(4-hydroxyphenyl)glycyl-(2R)-2-(3,5-dihydroxyphenyl)glycyl-L-valyl-(2R)-2-(3,5-dihydroxyphenyl)glycyl-(2S)-2-(4-hydroxyphenyl)glycyl-L-phenylalanyl-L-aspartic acid

Synonyms: 

Molecular weight: 1,900.90

CAS: 209335-49-9

Purity: ≥95%

Formulation: A solid

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