An ARE activator with cardioprotective activity; increases expression of an ARE-luciferase reporter construct in H9c2 cells in a concentration-dependent manner as well as mRNA expression of the ARE-regulated genes for GST Ya and HO-1 in neonatal rat cardiomyocytes; binds to MIF (Kd = 68.6 nM); increases expression of GST Ya in H9c2 cells in a MIF-dependent manner at 3 μM; inhibits cell death induced by serum deprivation or doxorubicin in neonatal rat cardiomyocytes in a concentration-dependent manner

BTZO-1 – 5 mg

Brand:
Cayman
CAS:
99420-15-2
Storage:
-20
UN-No:
Non-Hazardous - /

BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.{45205} It increases expression of an ARE-luciferase reporter construct in H9c2 cells in a concentration-dependent manner as well as mRNA expression of the ARE-regulated genes for the glutathione S-transferase Ya subunit (GST Ya) and heme oxygenase-1 (HO-1) in neonatal rat cardiomyocytes. BTZO-1 binds to macrophage migration inhibitory factor (MIF; Kd = 68.6 nM) and increases expression of GST Ya in H9c2 cells in a MIF-dependent manner when used at a concentration of 3 μM. It inhibits cell death induced by serum deprivation or doxorubicin (Item No. 15007) in neonatal rat cardiomyocytes in a concentration-dependent manner.  

 

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SKU: 28161 - 5 mg Category:

Description

An ARE activator with cardioprotective activity; increases expression of an ARE-luciferase reporter construct in H9c2 cells in a concentration-dependent manner as well as mRNA expression of the ARE-regulated genes for GST Ya and HO-1 in neonatal rat cardiomyocytes; binds to MIF (Kd = 68.6 nM); increases expression of GST Ya in H9c2 cells in a MIF-dependent manner at 3 μM; inhibits cell death induced by serum deprivation or doxorubicin in neonatal rat cardiomyocytes in a concentration-dependent manner

Formal name: 2-(2-pyridinyl)-4H-1,3-benzothiazin-4-one

Synonyms: 

Molecular weight: 240.3

CAS: 99420-15-2

Purity: ≥98%

Formulation: A solid

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