An internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC by GC- or LC-MS

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PC – 5 mg

Brand:
Cayman
CAS:
1872379-72-0
Storage:
-20
UN-No:
Non-Hazardous - /

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC (Item No. 10172) by GC- or LC-MS. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine.{11139} It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 µM.{42919} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 µM.{42920} It increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 µM.{42921} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.{11693}  

 

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Description

An internal standard for the quantification of 1-palmitoyl-2-hydroxy-sn-glycero-3-PC by GC- or LC-MS

Formal name: (7R)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphapentacosan-22,22,23,23,24,24,25,25,25-d9-1-aminium, 4-oxide, inner salt

Synonyms:  16:0(d9) Lyso PC|16:0-d9/0:0-PC|1-Hexadecanoyl-d9-sn-glycero-3-Phosphatidylcholine|1-Hexadecanoyl-d9-sn-glycero-3-Phosphocholine|PC(16:0-d9/0:0)

Molecular weight: 504.7

CAS: 1872379-72-0

Purity: ≥99% deuterated forms (d1-d9)

Formulation: A crystalline solid

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