A macrocyclic lactone; inhibits proliferation of a variety of cancer cell lines

Hygrolidin – 5 mg

Brand:
Cayman
CAS:
83329-73-1
Storage:
-20
UN-No:
Non-Hazardous - /

Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus.{46280} It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively).{46281} Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).{46282}  

 

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SKU: 28116 - 5 mg Category:

Description

A macrocyclic lactone; inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively); has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively)

Formal name: 2E-butenedioic acid, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester

Synonyms:  ,Antibiotic 1166C

Molecular weight: 690.9

CAS: 83329-73-1

Purity: ≥95%

Formulation: A solid

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