A depside lichen metabolite; active against the bacteria B. cereus

Atranorin – 5 mg

Brand:
Cayman
CAS:
479-20-9
Storage:
-20
UN-No:
Non-Hazardous - /

Atranorin is a depside lichen metabolite that has been found in S. alpinum and has diverse biological activities.{53784,53782,38112,53783} It is active against the bacteria B. cereus, B. subtilis, S. aureus, S. faecalis, P. vulgaris, L. monocytogenes, and A. hydrophila (MICs = 1.67, 0.38, 26.7, 13.4, 3.34, 9.83, and 1.67 mM, respectively), the fungi C. albicans and C. glabrata (MIC = 26.7 mM for both), as well as the mycobacterium M. aurum (MIC = 250 µg/ml).{53784,53782} Atranorin is cytotoxic to A270, HL-60, and Jurkat cancer cells (IC50s = 197.9, 93.5, and 181.6 µM, respectively) but not HeLa, MCF-7, SK-BR-3, or HT-29 cancer cells (IC50s = >200 µM).{38112} It inhibits acetic acid-induced writhing in mice when administered orally at doses of 200 and 400 mg/kg.{53783} Atranorin (200 and 400 mg/kg, p.o.) also reduces paw licking and biting in the second, but not first, phase of the formalin test when administered 30 minutes prior to formalin in mice.  

 

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Description

A depside lichen metabolite; active against the bacteria B. cereus, B. subtilis, S. aureus, S. faecalis, P. vulgaris, L. monocytogenes, and A. hydrophila (MICs = 1.67, 0.38, 26.7, 13.4, 3.34, 9.83, and 1.67 mM, respectively), the fungi C. albicans and C. glabrata (MIC = 26.7 mM for both), as well as the mycobacterium M. aurum (MIC = 250 µg/ml); cytotoxic to A270, HL-60, and Jurkat cancer cells (IC50s = 197.9, 93.5, and 181.6 µM, respectively) but not HeLa, MCF-7, SK-BR-3, or HT-29 cancer cells (IC50s = >200 µM); inhibits acetic acid-induced writhing in mice at 200 and 400 mg/kg; reduces paw licking and biting in the second, but not first, phase of the formalin test when administered 30 minutes prior to formalin in mice at 200 and 400 mg/kg

Formal name: 3-formyl-2,4-dihydroxy-6-methyl-benzoic acid, 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl ester

Synonyms:  NSC 249980|NSC 685591|NSC 87512

Molecular weight: 374.3

CAS: 479-20-9

Purity: ≥95%

Formulation: A crystalline solid

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