A polyether antibiotic; active against a variety of Gram-positive bacteria

Deethylindanomycin – 5 mg

Brand:
Cayman
CAS:
106803-22-9
Storage:
-20
UN-No:
Non-Hazardous - /

Deethylindanomycin is a polyether antibiotic that has been found in S. setonii.{47369,47370} It is active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of S. pneumoniae (MICs = 4, 4, and 2 µg/ml, respectively).{47370} It is also active against coccidia in vitro, inhibiting E. tenella development, but is inactive against E. tenella infection in chicks when administered at a dose of 200 µg/g in the diet. Deethylindanomycin acts as an ionophore in lipid bilayer membranes and is more selective for potassium ions than calcium, magnesium, and sodium ions.{47369} It induces histamine release from rodent mast cells and human basophils in vitro in a calcium-dependent manner.  

 

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SKU: 28089 - 5 mg Category:

Description

A polyether antibiotic; active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of S. pneumoniae (MICs = 4, 4, and 2 µg/ml); active against coccidia in vitro but not in vivo in chicks at 200 µg/g in the diet; acts as an ionophore in lipid bilayer membranes and is selective for potassium ions; induces histamine release from rodent mast cells and human basophils in vitro in a calcium-dependent manner

Formal name: (αR,2R,5S,6R)-6-[(1E,3E)-1-ethyl-4-[(3aR,4S,5S,7aS)-2,3,3a,4,5,7a-hexahydro-4-(1H-pyrrol-2-ylcarbonyl)-1H-inden-5-yl]-1,3-butadien-1-yl]tetrahydro-α,5-dimethyl-2H-pyran-2-acetic acid

Synonyms:  16-Deethylindanomycin|A 83094A|Omomycin

Molecular weight: 465.6

CAS: 106803-22-9

Purity: ≥95%

Formulation: A solid

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