An arachidonic acid metabolite; formed via epoxidation of arachidonic acid by cytochrome P450; prevents increases in LTB4

(±)14(15)-EET – 50 µg

Brand:
Cayman
CAS:
197508-62-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(±)14(15)-EET is a metabolite of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450.{463,729} It prevents increases in leukotriene B4 (LTB4; Item No. 20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.{60003} (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).{12606} It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.{60004}  

 

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Description

An arachidonic acid metabolite; formed via epoxidation of arachidonic acid by cytochrome P450; prevents increases in LTB4, ICAM-1, and CCL2 induced by oxidized LDL in primary RPAECs at 1 μM; induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM); reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by LAD occlusion at 0.128 mg/kg prior to occlusion or reperfusion

Formal name: (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid

Synonyms:  (±)14,15-EET|(±)14,15-EpETrE

Molecular weight: 320.5

CAS: 197508-62-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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