A mixture of ganglioside GM3 with variable fatty acyl chains; demonstrates antiproliferative and pro-apoptotic effects in tumor cells by modulating cell adhesion

Ganglioside GM3 Mixture (ammonium salt) – 1 mg

Brand:
Cayman
CAS:
54827-14-4
Storage:
-20
UN-No:
- /

Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and pro-apoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.{25490,25485} It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 μM via inhibition of VEGFR2 and Akt phosphorylation.{25490,25485} Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance in adipocytes.{25481} Ganglioside GM3 mixture contains ganglioside GM3 molecular species with variable fatty acyl chain lengths. [Matreya, LLC. Catalog No. 1503]  

 

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SKU: 31711 - 1 mg Category:

Description

A mixture of ganglioside GM3 with variable fatty acyl chains; demonstrates antiproliferative and pro-apoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation; suppresses angiogenesis and reduces proliferation and migration of HUVECs at 20 μM; induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains

Formal name:

Synonyms:  Hematoside Mixture|Sialosyllactosylceramide Mixture

Molecular weight: 1,268.70

CAS: 54827-14-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Sphingolipids

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