A mixture of ganglioside GM2 isolated from bovine brain with primarily C18:0 fatty acyl chain lengths; induces activated T cell death at 150 μg/ml in vitro; serum levels are increased in patients with breast cancer or cholangiocarcinoma; levels are elevated in the brain of patients with Sandhoff disease; accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency

Ganglioside GM2 Mixture (bovine brain) (ammonium salt) – 1 mg

Brand:
Cayman
CAS:
19600-01-2
Storage:
-20
UN-No:
- /

Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane.{43702} Gangliosides isolated from apoptogenic glioblastoma multiforme (GBM) cells are enriched in ganglioside GM2 compared with nonapoptogenic GBM cells, and ganglioside GM2 induces activated T cell death when used at a concentration of 150 μg/ml in vitro.{61125} Serum ganglioside GM2 levels are increased in patients with breast cancer or cholangiocarcinoma.{61126,61127} Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease.{40891} Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2.{40891,43703} Ganglioside GM2 mixture contains ganglioside GM2 molecular species isolated from bovine brain with primarily C18:0 fatty acyl chain lengths. [Matreya, LLC. Catalog No. 1542]  

 

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SKU: 31710 - 1 mg Category:

Description

A mixture of ganglioside GM2 isolated from bovine brain with primarily C18:0 fatty acyl chain lengths; induces activated T cell death at 150 μg/ml in vitro; serum levels are increased in patients with breast cancer or cholangiocarcinoma; levels are elevated in the brain of patients with Sandhoff disease; accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2

Formal name:

Synonyms:  GM2 Mixture|Monosialoganglioside GM2 Mixture

Molecular weight: 1,401.70

CAS: 19600-01-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Immunology||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders

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