Description
A bioactive sphingolipid; potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes; induces demyelination of mouse cerebellar slices at 0.1 and 1 µM; inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes; inhibits PPARα-mediated gene transcription in C6 glial cells at 10 and 15 µM; levels are increased in postmortem brain from patients with Krabbe disease
Formal name: (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl β-D-galactopyranoside
Synonyms: 1-β-D-Galactosylsphingosine|Galactosylsphingosine|Psychosine
Molecular weight: 461.6
CAS: 2238-90-6
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders
