A mixture of ganglioside GD1a molecular species with C14:0

Ganglioside GD1a Mixture (bovine) (ammonium salt) – 5 mg

Brand:
Cayman
CAS:
12707-58-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ganglioside GD1a is a sialic acid-containing glycosphingolipid that has been found in brain, erythrocytes, bone marrow, testis, spleen, and liver, as well as in serum lipoproteins.{54332,54333} It is shed into the tumor microenvironment from the surface of tumor cells, where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis.{25490} It functions as a toll-like receptor 2 (TLR2) co-receptor in isolated human monocytes, colocalizing with TLR2 and enhancing the binding of type IIb E. coli enterotoxin (LT-IIb-B5) to TLR2 when used at a concentration of 20 µM.{25484} Ganglioside GD1a (20 µM) increases VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs), as well as induces vascularization in a Matrigel™ plug assay in mice when used at a concentration of 20 µM/plug.{25490} It accumulates in the CNS of patients with galactosialidosis, a lysosomal storage disorder.{43703} Ganglioside GD1a mixture contains ganglioside GD1a molecular species with C14:0, C16:0, C18:0, C20:0, and C22:0 fatty acyl chains. [Matreya, LLC. Catalog No. 1062]  

 

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SKU: 31591 - 5 mg Category:

Description

A mixture of ganglioside GD1a molecular species with C14:0, C16:0, C18:0, C20:0, and C22:0 fatty acyl chains; a sialic acid-containing glycosphingolipid that has been found in brain, erythrocytes, bone marrow, testis, spleen, and liver, as well as serum lipoproteins; shed into the microenvironment from the surface of tumor cells, where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis; colocalizes with TLR2 and enhances the binding of LT-IIb-B5 to TLR2 at 20 µM; increases VEGF-induced proliferation of HUVECs at 20 µM; induces vascularization in a Matrigel™ plug assay in mice at 20 µM/plug; accumulates in the CNS of patients with galactosialidosis

Formal name:

Synonyms: 

Molecular weight: 1,872.20

CAS: 12707-58-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Tumor Microenvironment||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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