An inhibitor of prolyl hydroxylase; reduces levels of HIF-1α in rat liver and kidney; increases the expression of Epo

Desidustat – 100 mg

Brand:
Cayman
CAS:
1616690-16-4
Storage:
-20
UN-No:
Non-Hazardous - /

Desidustat is an inhibitor of prolyl hydroxylase (PHD).{52044} It reduces levels of hypoxia-inducible factor-1α (HIF-1α), a transcription factor regulated by PHD enzymes, in rat liver and kidney. Desidustat increases the expression of the red blood cell- and iron transport-related genes Epo, Fpn1, and Hamp in rat liver in a model of anemia induced by peptidoglycan-polysaccharide (PGPS).{52045} It increases plasma levels of erythropoietin in rats by 10.3- to 40-fold when administered at doses of 15 and 30 mg/kg, respectively.{52044} Desidustat (15 and 30 mg/kg) also increases plasma levels of erythropoietin and hemoglobin, as well as the number of circulating red blood cells, in nephrectomized rats in a model of chronic kidney disease-induced anemia. It increases hemoglobin levels and the number of circulating red blood cells in a mouse model of anemia induced by the DNA-crosslinking agent cisplatin (Item No. 13119).  

 

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Description

An inhibitor of prolyl hydroxylase; reduces levels of HIF-1α in rat liver and kidney; increases the expression of Epo, Fpn1, and Hamp in rat liver in a model of PGPS-induced anemia; increases plasma levels of erythropoietin in rats by 10.3- to 40-fold at 15 and 30 mg/kg, respectively; increases plasma levels of erythropoietin and hemoglobin, as well as the number of circulating red blood cells, in nephrectomized rats in a model of chronic kidney disease-induced anemia at 15 and 30 mg/kg

Formal name: N-[[1-(cyclopropylmethoxy)-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl]carbonyl]-glycine

Synonyms: 

Molecular weight: 332.3

CAS: 1616690-16-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Prolyl Hydroxylation Enzymes||Research Area|Cardiovascular System|Blood|Erythrocytes & Hemoglobin||Research Area|Cardiovascular System|Kidney & Renal Disease|Chronic Kidney Disease||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation

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