An antibiotic; active against a variety of bacteria

10′-Desmethoxystreptonigrin – 2.5 mg

Brand:
Cayman
CAS:
136803-89-9
Storage:
-20
UN-No:
Non-Hazardous - /

10’-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin.{49160} It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1, and 0.4 µg/ml, respectively).{49161} 10’-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 µg/ml, respectively), as well as HCT116 cells resistant to etoposide (Item No. 12092) and teniposide (Item No. 14425) and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 µg/ml, respectively). 10’-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM).  

 

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SKU: 28065 - 2.5 mg Category:

Description

An antibiotic; active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1, and 0.4 µg/ml, respectively); cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 µg/ml, respectively); cytotoxic to etoposide- and teniposide-resistant HCT116 cells and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 µg/ml, respectively); an inhibitor of p21ras farnesylation (IC50 = 21 nM)

Formal name: 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3-methoxyphenyl)-3-methyl-2-pyridinecarboxylic acid

Synonyms: 

Molecular weight: 476.4

CAS: 136803-89-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Cancer|Multidrug Resistance||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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