Description
A phenazine pigment and virulence factor produced by P. aeruginosa; increases ROS production in RAW 264.7 cells in a concentration-dependent manner; increases release of elastase and MPO by fMLP- and cytochalasin B-activated human neutrophils at ≥1.55 and ≥3.12 μM, respectively; reduces ciliary beat frequency in isolated guinea pig tracheal rings, resulting in ciliary dyskinesia by 1 hour at 10, 50, and 100 μM and ciliary stasis by 5 hours at 50 and 100 μM; reduces tracheal mucus velocity in anesthetized guinea pigs when administered as a 100 or 200 ng bolus dose; active against the plant pathogenic fungi F. graminearum, P. grisea, A. solani, F. oxysporium, and S. sclerotiorum (MICs = 2-50 μg/ml)
Formal name: 1-phenazinol
Synonyms: Hemipyocyanine|NSC 88882
Molecular weight: 196.2
CAS: 528-71-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides|Fungicides||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
