An agonist of the STING pathway; induces secretion of IFN-β in human PBMCs (EC50 = 130 nM); increases serum levels of IFN-β

diABZI STING Agonist 3 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
2138299-34-8
Storage:
-20
UN-No:
Non-Hazardous - /

diABZI STING agonist 3 is an agonist of the stimulator of interferon genes (STING) pathway.{43612} It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC50 = 130 nM). diABZI STING agonist 3 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.  

 

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SKU: 28054 - 1 mg Category:

Description

An agonist of the STING pathway; induces secretion of IFN-β in human PBMCs (EC50 = 130 nM); increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type mice at 2.5 mg/kg; decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg

Formal name: 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide, trihydrochloride

Synonyms: 

Molecular weight: 959.3

CAS: 2138299-34-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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