Description
An inhibitor of the interaction between PD-1 and its ligands, PD-L1 and PD-L2; inhibits binding of soluble PD-1 to HEK293 cells expressing human PD-L2 (EC50 = 0.72 nM); reverses PD-L1-induced inhibition of proliferation of PMA-stimulated, PD-1-expressing rat PBMCs (EC50 = 0.41 nM); reduces tumor growth and lung metastasis by 44 and >60%, respectively, in a B16/F10 mouse melanoma model at 5 mg/kg per day
Formal name: N2,N6-bis(L-seryl-L-asparaginyl-L-threonyl-L-seryl-L-α-glutamyl-L-seryl-L-phenylalanyl)-L-lysyl-L-phenylalanyl-L-arginyl-L-valyl-L-threonyl-L-glutaminyl-L-leucyl-L-alanyl-L-prolyl-L-lysyl-L-alanyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-α-glutamine
Synonyms: AUR-012|SNTSESFK(SNTSESF)FRVTQLAPKAQIKE-NH2
Molecular weight: 3,261.60
CAS: 1353563-85-5
Purity: ≥95%
Formulation: A solid
Product Type|Biochemicals|Peptides||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Immunology||Research Area|Immunology & Inflammation|Innate Immunity
