A major metabolite of pioglitazone; formed from pioglitazone by CYP2C8 with minor contributions from CYP3A4; binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a TR-FRET assay (EC50 = 2.1 μM)

Hydroxy Pioglitazone – 5 mg

Brand:
Cayman
CAS:
146062-44-4
Storage:
-20
UN-No:
Non-Hazardous - /

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028).{48274} It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4.{48275} Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).{48274}  

 

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SKU: 28043 - 5 mg Category:

Description

A major metabolite of pioglitazone; formed from pioglitazone by CYP2C8 with minor contributions from CYP3A4; binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a TR-FRET assay (EC50 = 2.1 μM)

Formal name: 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Synonyms: 

Molecular weight: 372.4

CAS: 146062-44-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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