A Nur77 receptor agonist; selectively activates Nur77 over PPARγ in reporter assays at 20 μM; inhibits growth of and induces apoptosis in L3.6pL pancreatic cancer cells at 10

C-DIM5 – 1 mg

Brand:
Cayman
CAS:
33985-68-1
Storage:
-20
UN-No:
Non-Hazardous - /

C-DIM5 is a para-phenyl-substituted diindolylmethane (C-DIM) and an agonist of the orphan receptor nuclear receptor-related protein 77 (Nur77).{49136} It selectively activates Nur77 over peroxisome proliferator receptor γ (PPARγ) in reporter assays when used at a concentration of 20 μM. C-DIM5 (10, 15, and 20 μM) inhibits growth of and induces apoptosis in L3.6pL pancreatic cancer cells.{49137} It stabilizes nuclear localization of Nur77 and Nurr1 and reduces secretion of the pro-inflammatory cytokines IL-2, IL-6, IL-12p70, CCL2, and CCL5 in primary mouse astrocytes.{49138} Oral administration of C-DIM5 (50 mg/kg) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and striatal dopamine terminals in a mouse model of Parkinson’s disease induced by MPTP.{49139}  

 

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SKU: 27980 - 1 mg Category:

Description

A Nur77 receptor agonist; selectively activates Nur77 over PPARγ in reporter assays at 20 μM; inhibits growth of and induces apoptosis in L3.6pL pancreatic cancer cells at 10, 15, and 20 μM; stabilizes nuclear localization of Nur77 and Nurr1 and reduces secretion of pro-inflammatory cytokines in primary mouse astrocytes; oral administration prevents loss of dopaminergic neurons in the substantia nigra pars compacta and striatal dopamine terminals in a mouse model of MPTP-induced Parkinson’s disease at 50 mg/kg,

Formal name: 3,3′-[(4-methoxyphenyl)methylene]bis-1H-indole

Synonyms:  DIM-C-pPhOCH3

Molecular weight: 352.4

CAS: 33985-68-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Transcription Factors||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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