A dual PI3K (IC50 = 4 nM for PI3Kα) and mTOR inhibitor (apparent Ki = 21 nM); inhibits proliferation of MCF-7.1 cells (EC50 = 143 nM); reduces tumor growth in a PC3-NCI tumor xenograft model at 1-20 mg/kg per day

GNE-477 – 10 mg

Brand:
Cayman
CAS:
1032754-81-6
Storage:
-20
UN-No:
Non-Hazardous - /

GNE-477 is a dual inhibitor of PI3K (IC50 = 4 nM for PI3Kα) and mTOR (apparent Ki = 21 nM).{48273} It inhibits proliferation of MCF-7.1 cells with an EC50 value of 143 nM. It reduces tumor growth in a PC3-NCI tumor xenograft model when administered at doses ranging from 1 to 20 mg/kg per day.  

 

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SKU: 27977 - 10 mg Category:

Description

A dual PI3K (IC50 = 4 nM for PI3Kα) and mTOR inhibitor (apparent Ki = 21 nM); inhibits proliferation of MCF-7.1 cells (EC50 = 143 nM); reduces tumor growth in a PC3-NCI tumor xenograft model at 1-20 mg/kg per day

Formal name: 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-2-pyrimidinamine

Synonyms: 

Molecular weight: 504.6

CAS: 1032754-81-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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