A diketopiperazine; active against S. aureus and B. subtilis (MICs = 16.3 and 18.2 µg/ml

Cyclo(L-Pro-L-Val) – 250 mg

Brand:
Cayman
CAS:
2854-40-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others.{47605,47606,47607} It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 µg/ml, respectively) but not E. coli (MIC = >20 µg/ml).{47607} Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026.{45034} However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.  

 

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SKU: 27961 - 250 mg Category:

Description

A diketopiperazine; active against S. aureus and B. subtilis (MICs = 16.3 and 18.2 µg/ml, respectively); modulates LuxR-dependent quorum sensing systems but not lacZ-based reporter fusions; inhibits activation of a LuxR-dependent E. coli biosensor by 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026

Formal name: (3S,8aS)-hexahydro-3-(1-methylethyl)-pyrrolo[1,2-a]pyrazine-1,4-dione

Synonyms:  Cyclo(L-prolyl-L-valine)

Molecular weight: 196.2

CAS: 2854-40-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing

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