An ERK1/2 inhibitor (IC50 = 5 nM for both); inhibits cell proliferation of tumor cells in vitro

LY3214996 – 10 mg

Brand:
Cayman
CAS:
1951483-29-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both).{42884} It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.  

 

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SKU: 27936 - 10 mg Category:

Description

An ERK1/2 inhibitor (IC50 = 5 nM for both); inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations in vitro; inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as PDX mouse models,

Formal name: 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one

Synonyms: 

Molecular weight: 453.6

CAS: 1951483-29-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|GTPases

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