Description
A modulator of γ-secretase that inhibits AICD cleavage to Aβ (IC50s = 531 and 131 nM for Aβ40 and Aβ42, respectively, in HeLa cell membranes); selective for AICD cleavage to Aβ over E-cadherin and Notch cleavage to E-cadherin γ-C-terminal fragments and NICD, respectively, at 30 µM; reduces cortical and hippocampal plaque area in Tg2576 mice at ~50 mg/kg per day; decreases plasma and brain Aβ40 and Aβ42 levels, as well as increases spontaneous alternations in the Y-maze in Tg2576 mice at 25 mg/kg per day
Formal name: N-(5-ethyl-2,4-dimethylphenyl)-4-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-thiazolamine
Synonyms:
Molecular weight: 406.5
CAS: 1304630-27-0
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease
