An inhibitor of c-Kit-driven cell proliferation; selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1

AZD 3229 – 5 mg

Brand:
Cayman
CAS:
2248003-60-1
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 3229 is an inhibitor of c-Kit-driven cell proliferation.{51097} It selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1,378 nM). AZD 3229 (20 mg/kg twice per day) induces tumor regression in a Ba/F3 mouse xenograft model and a mouse allograft model using Ba/F3 cells expressing KIT-exon 11 del/V654A, a common mutation in gastrointestinal stromal tumors (GIST).  

 

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SKU: 27908 - 5 mg Category:

Description

An inhibitor of c-Kit-driven cell proliferation; selectively inhibits growth of c-Kit mutant (GI50s = 1-971 nM) and PDGFR mutant (GI50s = 1-22 nM) Ba/F3 cell lines over Ba/F3 cell lines expressing Tel-KDR/VEGFR2 (GI50 = 1,378 nM); induces tumor regression in a Ba/F3 mouse xenograft model at 20 mg/kg per day; induces tumor regression in a mouse allograft model using Ba/F3 cells expressing KIT-exon 11 del/V654A at 20 mg/kg twice per day

Formal name: N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-1H-1,2,3-triazole-1-acetamide

Synonyms: 

Molecular weight: 479.5

CAS: 2248003-60-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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