A biflavonoid with diverse biological activities; cytotoxic to HeLa

Bilobetin – 5 mg

Brand:
Cayman
CAS:
521-32-4
Storage:
-20
UN-No:
Non-Hazardous - /

Bilobetin is a biflavonoid that has been found in G. biloba and has diverse biological activities.{51210,51211,51212} It is cytotoxic to HeLa, NCI-H460, Daudi, K562, SKOV3, MIA PaCa-2, and MCF-7 cells in vitro (IC50s = 14.79-97.28 μM).{51210} Bilobetin halts the cell cycle at the G2/M phase in HeLa cells in a concentration-dependent manner and induces apoptosis in HeLa cells when used at a concentration of 20 μM. It selectively inhibits matrix metalloproteinase-9 (MMP-9; IC50 = 10.33 μM) over MMP-2 and MMP-3 (IC50s = >100 μM).{51211} Bilobetin also inhibits aggregation of amyloid-β (1-40) peptide (Aβ40; Item No. 21617) in vitro with an IC50 value of 4.7 μM.{51212}  

 

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SKU: 27899 - 5 mg Category:

Description

A biflavonoid with diverse biological activities; cytotoxic to HeLa, NCI-H460, Daudi, K562, SKOV3, MIA PaCa-2, and MCF-7 cells in vitro (IC50s = 14.79-97.28 μM); halts the cell cycle at the G2/M phase in HeLa cells in a concentration-dependent manner; induces apoptosis in HeLa cells at 20 μM; selectively inhibits MMP-9 (IC50 = 10.33 μM) over MMP-2 and MMP-3 (IC50s = >100 μM); inhibits aggregation of Aβ40 in vitro (IC50 = 4.7 μM)

Formal name: 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 552.5

CAS: 521-32-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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