Description
A polyphenol with diverse biological activities; inhibits HIV-1 integrase 3′ end processing, 3’ end joining, and disintegration (IC50s = 0.13, 0.24, and 0.3 μg/ml, respectively); inhibits HIV-1 replication in MT-2 T lymphoblastoid cells (EC50 = 2 µg/ml); scavenges DPPH radicals in a cell-free assay (IC50 = 19.8 µM) and inhibits superoxide production in human neutrophils activated by fMLF and cytochalasin B (IC50 = 1.49 µM); decreases PGE2 production in LPS-stimulated U937 cells at 5 and 10 µg/ml but increases it at 200 µg/ml and increases TNF-α production at 5-200 µg/ml; inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis in B16F1 murine melanocytes at 25 µM
Formal name: (1R,3R,4S,5R)-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,5-dihydroxy-cyclohexanecarboxylic acid
Synonyms: 4,5-DCQA|Isochlorogenic Acid C
Molecular weight: 516.5
CAS: 57378-72-0
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic
