A triterpenoid with diverse biological activities; cytotoxic to HepG2

Corosolic Acid – 5 mg

Brand:
Cayman
CAS:
4547-24-4
Storage:
-20
UN-No:
Non-Hazardous - /

Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties.{42869,42870,42871,42872} It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively).{42869} Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) with an ID50 value of 0.09 mg/ear.{42870} It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg.{42871} Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.{42872}  

 

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Description

A triterpenoid with diverse biological activities; cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively); inhibits TPA-induced ear edema in mice (ID50 = 0.09 mg/ear); reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes at 2 and 10 mg/kg; reduces systolic blood pressure and serum levels of free fatty acids, TBARS, 8-OHdG, 3-nitrotyrosine, and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome at 0.072% in the diet

Formal name: 2α,3β-dihydroxy-urs-12-en-28-oic acid

Synonyms:  2α-Hydroxyursolic Acid|Glucosol

Molecular weight: 472.7

CAS: 4547-24-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Metabolic Syndrome||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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