An agonist of the STING pathway; induces secretion of type I IFN from THF and MM6 cells at 50 μM; induces phosphorylation of IRF3 and increases expression of IFIT1 and viperin in THF cells in a STING-dependent manner; reduces viral titers of chikungunya

STING Agonist C11 – 10 mg

Brand:
Cayman
CAS:
875863-22-2
Storage:
-20
UN-No:
Non-Hazardous - /

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.{35844} It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o’nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α/β receptor (IFNAR).  

 

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SKU: 27886 - 10 mg Category:

Description

An agonist of the STING pathway; induces secretion of type I IFN from THF and MM6 cells at 50 μM; induces phosphorylation of IRF3 and increases expression of IFIT1 and viperin in THF cells in a STING-dependent manner; reduces viral titers of chikungunya, Venezuelan equine encephalitis, o’nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and IFNAR

Formal name: N-[(methylamino)carbonyl]-α-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]-benzeneacetamide

Synonyms: 

Molecular weight: 382.4

CAS: 875863-22-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease|Viral Diseases|Chikungunya

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