An aminoglycoside antibiotic and a derivative of streptomycin; active against B. subtilis

Dihydrostreptomycin (sulfate) – 250 g

Brand:
Cayman
CAS:
5490-27-7
Storage:
-20
UN-No:
Non-Hazardous - /

Dihydrostreptomycin is an aminoglycoside antibiotic and a derivative of streptomycin (Item No. 21211).{47596} It is active against B. subtilis, K. pneumoniae, S. marcescens, S. aureus, P. aeruginosa, and M. tuberculosis (MICs = 0.07, 0.08, 0.09, 0.06, 0.8, and 5.7 µg/ml, respectively). It interferes with bacterial protein synthesis by binding the 30S ribosomal subunit.{47595} Dihydrostreptomycin enhances phagocytosis and intracellular killing of E. coli by isolated mouse peritoneal macrophages.{47597} It improves survival in a mouse model of S. aureus infection.{47598} Formulations containing dihydrostreptomycin have been used in the prevention and treatment of bacterial infections in livestock.  

 

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SKU: 27879 - 250 g Category:

Description

An aminoglycoside antibiotic and a derivative of streptomycin; active against B. subtilis, K. pneumoniae, S. marcescens, S. aureus, P. aeruginosa, and M. tuberculosis (MICs = 0.07, 0.08, 0.09, 0.06, 0.8, and 5.7 µg/ml, respectively); interferes with bacterial protein synthesis by binding the 30S ribosomal subunit; enhances phagocytosis and intracellular killing of E. coli by isolated mouse peritoneal macrophages; improves survival in a mouse model of S. aureus infection

Formal name: O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-D-streptamine, sulfate (2:3)

Synonyms: 

Molecular weight: 730.7

CAS: 5490-27-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Aminoglycosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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