An inhibitor of cathepsin L (Kinact = 200

Z-Phe-Tyr(tBu)-diazomethylketone – 25 mg

Brand:
Cayman
CAS:
114014-15-2
Storage:
-20
UN-No:
Non-Hazardous - /

Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L (Kinact = 200,000 M-1s-1).{42899,42900} It is selective for cathepsin L over cathepsin S and cathepsin B (Kinacts = 30 and 10.3 M-1s-1, respectively). Z-Phe-Tyr(tBu)-diazomethylketone is active against bloodstream forms of T. brucei brucei clone 427-221a in vitro (EC50 = 126 μM).{41145}  

 

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SKU: 27877 - 25 mg Category:

Description

An inhibitor of cathepsin L (Kinact = 200,000 M-1s-1); selective for cathepsin L over cathepsin S and cathepsin B (Kinacts = 30 and 10.3 M-1s-1, respectively); active against bloodstream forms of T. brucei brucei clone 427-221a in vitro (EC50 = 126 μM)

Formal name: N-[(1S)-2-[[(1S)-3-diazo-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester

Synonyms:  Cbz-Phe-Tyr(O-t-Bu)-CHN2|Z-Phe-Tyr(tBu)-CHN2

Molecular weight: 542.6

CAS: 114014-15-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness

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