Description
An inhibitor of oxidative phosphorylation in cancer cells; increases the mitochondrial membrane potential and inhibits the oxygen consumption rate, indicating F0F1 ATP synthase/complex V inhibition; decreases viability of three primary mouse glioblastoma cell lines (IC50s = ~150 nM) and three patient-derived glioblastoma cultures (IC50s = ~1 µM) but does not affect the viability of primary mouse embryonic fibroblasts or astrocytes; halts the cell cycle and induces apoptosis
Formal name: 2-ethyl-1-methyl-3-[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-2-oxoethyl]-1H-benzimidazolium, monochloride
Synonyms:
Molecular weight: 393
CAS: 2101315-36-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis
