A major metabolite of efavirenz; formed when efavirenz is metabolized by CYP2B6; induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures at 0.01 μM

8-hydroxy Efavirenz – 1 mg

Brand:
Cayman
CAS:
205754-33-2
Storage:
-20
UN-No:
Non-Hazardous - /

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz (Item No. 14412).{49116} 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.{49117}  

 

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SKU: 27853 - 1 mg Category:

Description

A major metabolite of efavirenz; formed when efavirenz is metabolized by CYP2B6; induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures at 0.01 μM,

Formal name: (4S)-6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

Synonyms: 

Molecular weight: 331.7

CAS: 205754-33-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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