Description
An active metabolite of sorafenib; inhibits FLT3-ITD (Kd = 70 nM); inhibits proliferation of MV4-11 AML cells expressing FLT3-ITD (IC50 = 25.8 nM); selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 µM); a linear-mixed inhibitor of CYP3A4 (Ki = 15 µM)
Formal name: 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide, 1-oxide
Synonyms: BAY 67-3472
Molecular weight: 480.8
CAS: 583840-03-3
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Ox Stress Reagents||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Toxicology|Drug Metabolism|Cytochrome P450
