A PPARγ-sparing thiazolidinedione derivative; binds only weakly to PPARγ (IC50 = 18.25 µM) and induces minimal activation of a Gal4-PPARγ reporter construct at 50 µM; decreases the pyruvate-induced oxygen consumption rate in control mitochondria but not in LS-Mpc2-/- mitochondria; reduces body weight gain and adiposity

MSDC-0602 – 25 mg

Brand:
Cayman
CAS:
1133819-87-0
Storage:
-20
UN-No:
Non-Hazardous - /

MSDC-0602 is a PPARγ-sparing thiazolidinedione derivative.{43414} It binds only weakly to PPARγ (IC50 = 18.25 µM) and induces minimal activation of a Gal4-PPARγ reporter construct when used at a concentration of 50 µM. MSDC-0602 binds to mitochondrial membranes and decreases the pyruvate-induced oxygen consumption rate in control mitochondria but not in liver-specific mitochondrial pyruvate carrier 2 knockout (LS-Mpc2-/-) mitochondria.{43423} It reduces body weight gain and adiposity, as well as increases intrascapular brown adipose tissue (BAT) mass in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-trans-fat, -fructose, and -cholesterol diet when administered in the diet for 12 weeks, starting four weeks after the beginning of the diet.{43424} It also reverses hepatic fibrosis and stellate cell fibrinogenesis when administered for three weeks, starting 16 weeks after the beginning of the diet. MSDC-0602 decreases plasma glucose, triglyceride, and cholesterol levels in ob/ob mice and increases insulin sensitivity in the striatal muscle, adipose tissue, and liver of diet-induced obese mice.{43414}  

 

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SKU: 27829 - 25 mg Category:

Description

A PPARγ-sparing thiazolidinedione derivative; binds only weakly to PPARγ (IC50 = 18.25 µM) and induces minimal activation of a Gal4-PPARγ reporter construct at 50 µM; decreases the pyruvate-induced oxygen consumption rate in control mitochondria but not in LS-Mpc2-/- mitochondria; reduces body weight gain and adiposity, as well as increases intrascapular BAT mass in a mouse model of NASH; reverses hepatic fibrosis and stellate cell fibrinogenesis in a mouse model of NASH; decreases plasma glucose, triglyceride, and cholesterol levels in ob/ob mice and increases insulin sensitivity in the striatal muscle, adipose tissue, and liver of diet-induced obese mice

Formal name: 5-[[4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Synonyms: 

Molecular weight: 371.4

CAS: 1133819-87-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Thermogenesis

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