A derivative of lycorine with antihypertensive and neuroprotective activities; inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle (pA2s = 5.93 and 6.35

Dihydrolycorine – 10 mg

Brand:
Cayman
CAS:
6271-21-2
Storage:
-20
UN-No:
- /

Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities.{45310} It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.{45311}  

 

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SKU: 27809 - 10 mg Category:

Description

A derivative of lycorine with antihypertensive and neuroprotective activities; inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle (pA2s = 5.93 and 6.35, respectively); reduces MAP in anesthetized and conscious normotensive rats at 80 mg/kg; reduces electrically or phenylephrine-induced hypertension in pithed rats; reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion

Formal name: (1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol

Synonyms: 

Molecular weight: 289.3

CAS: 6271-21-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase

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