A coumarin with diverse biological activities; inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM

Xanthotoxol – 10 mg

Brand:
Cayman
CAS:
2009-24-7
Storage:
-20
UN-No:
Non-Hazardous - /

Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities.{47083,45339,45340,45341,45342} It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively).{47083} Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA).{45339} It is nematocidal against M. incognita (IC50 = 68 mg/L).{45340} In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively.{45341} It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.{45342}  

 

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Description

A coumarin with diverse biological activities; inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively); increases histamine release from mast cells; decreases DNP-HSA-induced secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells; nematocidal against M. incognita (IC50 = 68 mg/L); inhibits predatory mouse and rat killing behavior in dogs and cats at 3-100 and 5-20 mg/kg, respectively; reduces amphetamine-induced hypermobility in mice and hamsters; reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and NO, and intercellular levels of ICAM-1 and E-selectin in a rat model of focal cerebral ischemia at 5 and 10 mg/kg

Formal name: 9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms:  8-Hydroxypsoralen|NSC 401269|Xanthotol

Molecular weight: 202.2

CAS: 2009-24-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Behavioral Neuroscience||Research Area|Neuroscience|Neuroprotection|Ischemia

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