An inhibitor of tyrosine hydroxylase (Ki = 0.39 µM) and an intermediate in the synthesis of thyroid hormones; has been incorporated into proteins as a non-natural amino acid for use as a label to detect protein-protein interactions; induces the formation of α-synuclein aggregates and tyrosine hydroxylase-positive inclusions in primary substantia nigra neurons at 5 and 10 nM; reduces locomotor activity and induces bradykinesia in the open field test at 10 µM

3-Iodotyrosine – 5 g

Brand:
Cayman
CAS:
70-78-0
Storage:
-20
UN-No:
Non-Hazardous - /

3-Iodotyrosine is an inhibitor of tyrosine hydroxylase (Ki = 0.39 µM) and an intermediate in the synthesis of thyroid hormones.{51108,51109} It has been incorporated into proteins as a non-natural amino acid for use as a label to detect protein-protein interactions.{51110} 3-Iodotyrosine induces the formation of α-synuclein aggregates and tyrosine hydroxylase-positive inclusions in primary substantia nigra neurons when used at concentrations of 5 and 10 nM.{51111} It induces parkinsonism in mice, reducing locomotor activity and inducing bradykinesia in the open field test when administered at an intrastriatal dose of 10 µM.  

 

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SKU: 27798 - 5 g Category:

Description

An inhibitor of tyrosine hydroxylase (Ki = 0.39 µM) and an intermediate in the synthesis of thyroid hormones; has been incorporated into proteins as a non-natural amino acid for use as a label to detect protein-protein interactions; induces the formation of α-synuclein aggregates and tyrosine hydroxylase-positive inclusions in primary substantia nigra neurons at 5 and 10 nM; reduces locomotor activity and induces bradykinesia in the open field test at 10 µM

Formal name: 3-iodo-L-tyrosine

Synonyms:  3-iodo-4-Hydroxyphenylalanine|Monoiodotyrosine|NSC 210787

Molecular weight: 307.1

CAS: 70-78-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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