A lignan with diverse biological activities; an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine

(+)-Pinoresinol – 25 mg

Brand:
Cayman
CAS:
487-36-5
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{45351,45352,45353,45354} It is an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively).{45353} (+)-Pinoresinol scavenges ABTS (Item No. 27317), but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), radicals in cell-free assays (IC50s = 13.43 and >200 µg/ml, respectively).{45352} It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC50 values of 29.35, 62.35, 75.32, >80, and >80 µM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 µM).{45354}  

 

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SKU: 27700 - 25 mg Category:

Description

A lignan with diverse biological activities; an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively); scavenges ABTS, but not DPPH, radicals in cell-free assays (IC50s = 13.43 and >200 µg/ml, respectively); cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells (IC50s = 29.35, 62.35, 75.32, >80, and >80 µM, respectively); prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 µM)

Formal name: 4,4′-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxy-phenol

Synonyms:  NSC 35444

Molecular weight: 358.4

CAS: 487-36-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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