An α1B-AR antagonist (Ki = 0.45 nM for the recombinant human receptor); selectively inhibits α1B-ARs over α1A-

Rec 15/2615 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1782573-48-1
Storage:
-20
UN-No:
Non-Hazardous - /

Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor).{53296} It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM).{53295} It decreases diastolic blood pressure (ED25 = 183 µg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 µg/kg.{53296,53295}  

 

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SKU: 27677 - 10 mg Category:

Description

An α1B-AR antagonist (Ki = 0.45 nM for the recombinant human receptor); selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively); inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), and reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50 nM); decreases diastolic blood pressure (ED25 = 183 µg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at 30-1,000 µg/kg

Formal name: 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-[2-methoxy-6-(1-methylethyl)phenoxy]-ethanone, dihydrochloride

Synonyms:  SB 216469

Molecular weight: 568.5

CAS: 1782573-48-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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