An mTOR inhibitor (Kd = 6.3 nM); 1

CZ415 – 10 mg

Brand:
Cayman
CAS:
1429639-50-8
Storage:
-20
UN-No:
Non-Hazardous - /

CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM).{47760} It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.{47761}  

 

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SKU: 27668 - 10 mg Category:

Description

An mTOR inhibitor (Kd = 6.3 nM); 1,000-fold selective for mTOR over a panel of 285 kinases; inhibits phosphorylation of S6RP and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively); inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM); reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis at 10 mg/kg; inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model at 20 mg/kg

Formal name: N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N’-ethyl-urea

Synonyms: 

Molecular weight: 459.6

CAS: 1429639-50-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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