A dual inhibitor of CK2 and ERK8 (IC50 = 0.5 µM for both); binds to Pim-1

TMCB – 5 mg

Brand:
Cayman
CAS:
1085822-09-8
Storage:
-20
UN-No:
Non-Hazardous - /

TMCB is a dual inhibitor of casein kinase 2 (CK2) and ERK8 (IC50 = 0.5 µM for both).{22896} It also binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 µM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 µM. TMCB induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 µM.  

 

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SKU: 27652 - 5 mg Category:

Description

A dual inhibitor of CK2 and ERK8 (IC50 = 0.5 µM for both); binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 µM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 µM; induces apoptosis in Jurkat cells at 10-50 µM

Formal name: 4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acid

Synonyms: 

Molecular weight: 534.8

CAS: 1085822-09-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK2||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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