An inhibitor of EGFR and HER2 (IC50s = 7 and 2 nM

Varlitinib – 1 mg

Brand:
Cayman
CAS:
845272-21-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Varlitinib is an inhibitor of EGFR and HER2 (IC50s = 7 and 2 nM, respectively).{48649,48650} It inhibits cell proliferation (IC50s = In vivo, varlitinib (100 mg/kg) inhibits phosphorylation of EGFR and ERK and reduces tumor weight in an MDA-MB-468 mouse xenograft model.  

 

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SKU: 27651 - 1 mg Category:

Description

An inhibitor of EGFR and HER2 (IC50s = 7 and 2 nM, respectively); inhibits cell proliferation (IC50s = <20 μM) and induces apoptosis in MDA-MB-453 and MDA-MB-468 TNBC cells; inhibits phosphorylation of EGFR and ERK and reduces tumor weight in an MDA-MB-468 mouse xenograft model at 100 mg/kg

Formal name: N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-quinazolinediamine

Synonyms:  ARRY-334543

Molecular weight: 466.9

CAS: 845272-21-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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