A G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay); inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays; antagonizes dopamine-induced β-arrestin recruitment in cell-based assays (IC50s = 3.8-9.9 μM); inhibitor of type II secretion in Gram-negative bacteria; inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM

MLS-1547 – 10 mg

Brand:
Cayman
CAS:
315698-36-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

MLS-1547 is a G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay).{42964} It inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays. MLS-1547 antagonizes dopamine-induced β-arrestin recruitment in cell-based assays with IC50 values ranging from 3.8 to 9.9 μM.{42964} It is also an inhibitor of type II secretion in Gram-negative bacteria.{42965} MLS-1547 inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM, respectively) and inhibits B. pseudomallei protease secretion by 90.8% when used at a concentration of 25 μM.  

 

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SKU: 27648 - 10 mg Category:

Description

A G protein-biased agonist of dopamine D2 receptors (EC50 = 0.37 μM in a calcium mobilization assay); inhibits forskolin-induced cAMP accumulation in CHO cells expressing human D2 receptors (EC50 = 0.26 μM) but is inactive in β-arrestin recruitment assays; antagonizes dopamine-induced β-arrestin recruitment in cell-based assays (IC50s = 3.8-9.9 μM); inhibitor of type II secretion in Gram-negative bacteria; inhibits secretion of phospholipase C (PlcH/N) and the virulence factor elastase (LasB) from P. aeruginosa (IC50s = 15 and 13 μM, respectively) and inhibits B. pseudomallei protease secretion by 90.8% at 25 μM

Formal name: 5-chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol

Synonyms: 

Molecular weight: 354.8

CAS: 315698-36-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience

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