An NHE1 inhibitor (IC50s = 6 and 31 nM in pHi and human platelet swelling assays

BI-9627 – 10 mg

Brand:
Cayman
CAS:
1204329-34-9
Storage:
-20
UN-No:
Non-Hazardous - /

BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), with IC50 values of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively.{48743} It is greater than 30-fold selective for NHE1 over NHE2 and is inactive at NHE3 up to 16 μM in a pHi assay. BI-9627 inhibits phenylephrine-induced hypertrophy in neonatal rat cardiomyocytes.{48744} It increases recovery of left ventricular developed pressure and inhibits increases in left ventricular end-diastolic pressure (LVEDP) in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury when used at a concentration of 100 nM.{48743} BI-9627 (45 and 150 ppm in the diet) also attenuates decreases in left ventricular end-systolic pressure and increases in LVEDP in coronary artery-ligated rats.{48744}  

 

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SKU: 27640 - 10 mg Category:

Description

An NHE1 inhibitor (IC50s = 6 and 31 nM in pHi and human platelet swelling assays, respectively); greater than 30-fold selective for NHE1 over NHE2 and is inactive at NHE3 up to 16 μM in a pHi assay; inhibits phenylephrine-induced hypertrophy in neonatal rat cardiomyocytes; increases recovery of left ventricular developed pressure and inhibits increases in LVEDP in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury at 100 nM; attenuates decreases in left ventricular end-systolic pressure and increases in LVEDP in coronary artery-ligated rats at 45 and 150 ppm in the diet

Formal name: 4-(1-acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)-benzamide

Synonyms: 

Molecular weight: 356.3

CAS: 1204329-34-9

Purity: ≥95% (mixture of tautomers)

Formulation: A solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy

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