An antagonist of CRTH2/DP2 (IC50 = 42 nM in a radioligand binding assay); selective for binding to CRTH2/DP2 over DP1

BI-671800 – 1 mg

Brand:
Cayman
CAS:
1093108-50-9
Storage:
-20
UN-No:
Non-Hazardous - /

BI-671800 is an antagonist of the prostaglandin D2 (PGD2; Item No. 12010) receptor CRTH2/DP2 (IC50 = 42 nM in a radioligand binding assay).{17373} It binds selectively to CRTH2/DP2 over DP1, thromboxane, and prostacyclin receptors (IC50s = 25.6, 62.6, and >100 μM, respectively). BI-671800 inhibits PGD2-induced shape change in human eosinophils (IC50 = 744 nM).  

 

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Description

An antagonist of CRTH2/DP2 (IC50 = 42 nM in a radioligand binding assay); selective for binding to CRTH2/DP2 over DP1, thromboxane, and prostacyclin receptors (IC50s = 25.6, 62.6, and >100 μM, respectively); inhibits PGD2-induced shape change in human eosinophils (IC50 = 744 nM)

Formal name: 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-5-pyrimidineacetic acid

Synonyms:  AP-761

Molecular weight: 501.5

CAS: 1093108-50-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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