A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM

Swertiamarin – 10 mg

Brand:
Cayman
CAS:
17388-39-5
Storage:
-20
UN-No:
Non-Hazardous - /

Swertiamarin is an orally bioavailable secoiridoid glycoside that has been found in E. axillare and has diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective properties.{53028,53029,53030,53031,53032} It scavenges ABTS (Item No. 27317) radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively).{53028} Swertiamarin (50 μg/ml) inhibits nitric oxide (NO) production in IL-1β-stimulated fibroblast-like synoviocytes (FLSs) isolated from rat hindpaw.{53029} Swertiamarin (25 μg/ml) inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells.{53031} It decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced nonalcoholic fatty liver disease (NAFLD) when administered at a dose of 50 mg/kg per day.{53032} Swertiamarin (50 mg/kg per day) also decreases fasting blood glucose and serum cholesterol levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{53030}  

 

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SKU: 27634 - 10 mg Category:

Description

A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively); inhibits NO production in IL-1β-stimulated FLSs isolated from rat hindpaw at 50 μg/ml; inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells at 25 μg/ml; decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced NAFLD at 50 mg/kg per day; decreases fasting blood glucose and serum cholesterol levels in rat model of STZ-induced diabetes at 50 mg/kg per day,

Formal name: (4aR,5R,6S)-5-ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one

Synonyms: 

Molecular weight: 374.3

CAS: 17388-39-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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