A CCR4 receptor antagonist; inhibits CCL22-induced calcium flux (IC50 = 31.6 nM); inhibits CCL22- and CCL17-mediated chemotaxis of Th2 cells (IC50 = 501.2 nM); reduces alveolitis and leukocyte infiltration in lungs of antigen-challenged

AZD 2098 – 5 mg

Brand:
Cayman
CAS:
566203-88-1
Storage:
-20
UN-No:
Non-Hazardous - /

AZD 2098 is a CC chemokine receptor 4 (CCR4) antagonist.{50101} AZD 2098 inhibits CCL22-induced calcium flux in CHO cells expressing human recombinant CCR4 (IC50 = 31.6 nM) and CCL22- and CCL17-mediated Th2 cell chemotaxis (IC50 = 501.2 nM for both). AZD 2098 is selective for CCR4 over CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 up to 10 µM in vitro. Administration of AZD 2098 (0.07-2.5 mg/kg, p.o.) to ovalbumin-sensitized, antigen-challenged rats reduces alveolitis and leukocyte infiltration in the lung in a dose-dependent manner.  

 

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SKU: 27633 - 5 mg Category:

Description

A CCR4 receptor antagonist; inhibits CCL22-induced calcium flux (IC50 = 31.6 nM); inhibits CCL22- and CCL17-mediated chemotaxis of Th2 cells (IC50 = 501.2 nM); reduces alveolitis and leukocyte infiltration in lungs of antigen-challenged, ovalbumin sensitized rats in a dose-dependent manner (0.07-2.5 mg/kg, p.o.)

Formal name: 2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-benzenesulfonamide

Synonyms: 

Molecular weight: 334.2

CAS: 566203-88-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy

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