A bacterial metabolite with diverse biological activities; active against a variety of bacteria (MICs = 6.25 and 100 µg/ml) and fungi (MICs = 12.5-100 µg/ml); inhibits proliferation of A549 lung

Collismycin A – 1 mg

Brand:
Cayman
CAS:
158792-24-6
Storage:
-20
UN-No:
Non-Hazardous - /

Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties.{49147} It is active against a variety of bacteria (MICs = 6.25 and 100 µg/ml) and fungi (MICs = 12.5-100 µg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 µM, respectively) and NIH373 fibroblasts (IC50 = 56.6 µM) but not MDA-MD-231 breast cancer cells (IC50 = >100 µM).{49148,49149} Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.{49149} Collismycin A (1 µM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid (Item No. 11017).{49148}  

 

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SKU: 27622 - 1 mg Category:

Description

A bacterial metabolite with diverse biological activities; active against a variety of bacteria (MICs = 6.25 and 100 µg/ml) and fungi (MICs = 12.5-100 µg/ml); inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 µM, respectively) and NIH373 fibroblasts (IC50 = 56.6 µM) but not MDA-MD-231 breast cancer cells (IC50 = >100 µM); forms a complex with Fe(II) and Fe(III), and the antiproliferative effect on HeLa cells is blocked by the addition of iron ions; prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of all-trans retinoic acid-induced neuronal cell death

Formal name: [C(E)]-4-methoxy-5-(methylthio)-[2,2′-bipyridine]-6-carboxaldehyde oxime

Synonyms:  SF 2738A

Molecular weight: 275.3

CAS: 158792-24-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Neuroscience|Neuroprotection

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